| Wed, Oct 8 | @ |   Toronto Maple Leafs | SN1, TVAS | L 2-5 |
| Thu, Oct 9 | @ |   Detroit Red Wings | TSN2, RDS | W 5-1 |
| Sat, Oct 11 | @ |   Chicago Blackhawks | SNE, TVAS, CITY · NHLN(US) | W 3-2 |
| Tue, Oct 14 | vs |   Seattle Kraken | TSN2, RDS | W 5-4 (OT) |
| Thu, Oct 16 | vs |   Nashville Predators | TSN2, RDS | W 3-2 (OT) |
| Sat, Oct 18 | vs |   New York Rangers | SNE, TVAS, CITY | L 3-4 |
| Mon, Oct 20 | vs |   Buffalo Sabres | Prime, RDS | W 4-2 |
| Wed, Oct 22 | @ |   Calgary Flames | SN, RDS | W 2-1 (OT) |
| Thu, Oct 23 | @ |   Edmonton Oilers | TSN2, RDS, SNW | L 5-6 |
| Sat, Oct 25 | @ |   Vancouver Canucks | CBC, TVAS | W 4-3 |
| Tue, Oct 28 | @ | Seattle Kraken | TSN2, RDS | W 4-3 (OT) |
| Sat, Nov 1 | vs |   Ottawa Senators | SN1, TVAS | W 4-3 (OT) |
| Tue, Nov 4 | vs |   Philadelphia Flyers | TSN2, RDS | OTL 4-5 (SO) |
| Thu, Nov 6 | @ |   New Jersey Devils | TSN2, RDS | OTL 3-4 (OT) |
| Sat, Nov 8 | vs |   Utah Mammoth | SNE, TVAS, CITY | W 6-2 |
| Tue, Nov 11 | vs |   Los Angeles Kings | TSN2, RDS | L 1-5 |
| Thu, Nov 13 | vs |   Dallas Stars | TSN2, RDS | L 0-7 |
| Sat, Nov 15 | vs |   Boston Bruins | SNE, TVAS, CITY · NHLN(US) | L 2-3 |
| Mon, Nov 17 | @ |   Columbus Blue Jackets | Prime, RDS | OTL 3-4 (SO) |
| Thu, Nov 20 | vs |   Washington Capitals | TSN2, RDS | L 4-8 |
| Sat, Nov 22 | vs | Toronto Maple Leafs | SN, CBC, TVAS | W 5-2 |
| Wed, Nov 26 | @ | Utah Mammoth | TSN2, RDS | W 4-3 |
| Fri, Nov 28 | @ |   Vegas Golden Knights | TSN2, RDS | W 4-1 |
| Sat, Nov 29 | @ |   Colorado Avalanche | TSN2, RDS | L 2-7 |
| Tue, Dec 2 | vs | Ottawa Senators | TSN2, RDS, TSN5 | L 2-5 |
| Wed, Dec 3 | vs |   Winnipeg Jets | SN, RDS | W 3-2 (SO) |
| Sat, Dec 6 | @ | Toronto Maple Leafs | SN, CBC, TVAS | W 2-1 (SO) |
| Sun, Dec 7 | vs |   St. Louis Blues | TSN2, RDS | L 3-4 |
| Tue, Dec 9 | vs |   Tampa Bay Lightning | TSN2, RDS | L 1-6 |
| Thu, Dec 11 | @ |   Pittsburgh Penguins | TSN2, RDS | W 4-2 |
| Sat, Dec 13 | @ | New York Rangers | SNE, TVAS, CITY | OTL 4-5 (OT) |
| Sun, Dec 14 | vs | Edmonton Oilers | TSN2, RDS, SNW · NHLN(US) | W 4-1 |
| Tue, Dec 16 | vs | Philadelphia Flyers | TSN2, RDS | L 1-4 |
| Thu, Dec 18 | vs | Chicago Blackhawks | TSN2, RDS | W 4-1 |
| Sat, Dec 20 | vs | Pittsburgh Penguins | SNE, TVAS, CITY | W 4-0 |
| Sun, Dec 21 | @ | Pittsburgh Penguins | TSN2, RDS | OTL 3-4 (SO) |
| Tue, Dec 23 | @ | Boston Bruins | TSN2, RDS | W 6-2 |
| Sun, Dec 28 | @ | Tampa Bay Lightning | TSN2, RDS | OTL 4-5 (SO) |
| Tue, Dec 30 | @ |   Florida Panthers | TSN2, RDS | W 3-2 (OT) |
| Thu, Jan 1 | @ |   Carolina Hurricanes | TSN2, RDS | W 7-5 |
| Sat, Jan 3 | @ | St. Louis Blues | TSN2, RDS | L 0-2 |
| Sun, Jan 4 | @ | Dallas Stars | TSN2, RDS | W 4-3 (OT) |
| Wed, Jan 7 | vs | Calgary Flames | SN, RDS | W 4-1 |
| Thu, Jan 8 | vs | Florida Panthers | TSN2, RDS | W 6-2 |
| Sat, Jan 10 | vs | Detroit Red Wings | SNE, TVAS, CITY | L 0-4 |
| Mon, Jan 12 | vs | Vancouver Canucks | Prime, RDS | W 6-3 |
| Tue, Jan 13 | @ | Washington Capitals | TSN2, RDS | OTL 2-3 (OT) |
| Thu, Jan 15 | @ | Buffalo Sabres | TSN2, RDS | L 3-5 |
| Sat, Jan 17 | @ | Ottawa Senators | SNE, TVAS, CITY | W 6-5 (OT) |
| Tue, Jan 20 | vs |   Minnesota Wild | TSN2, RDS | W 4-3 |
| Thu, Jan 22 | vs | Buffalo Sabres | TSN2, RDS | L 2-4 |
| Sat, Jan 24 | @ | Boston Bruins | SN, CBC, TVAS · NHLN(US) | L 3-4 |
| Tue, Jan 27 | vs | Vegas Golden Knights | TSN2, RDS | W 3-2 (OT) |
| Thu, Jan 29 | vs | Colorado Avalanche | TSN2, RDS | W 7-3 |
| Sat, Jan 31 | @ | Buffalo Sabres | SNE, TVAS, CITY · NHLN(US) | W 4-2 |
| Mon, Feb 2 | @ | Minnesota Wild | Prime, RDS | OTL 3-4 (OT) |
| Wed, Feb 4 | @ | Winnipeg Jets | SN, RDS | W 5-1 |
| Thu, Feb 26 | vs |   New York Islanders | TSN2, RDS | OTL 3-4 (OT) |
| Sat, Feb 28 | vs | Washington Capitals | SNE, TVAS, CITY | W 6-2 |
| Tue, Mar 3 | @ |   San Jose Sharks | TSN2, RDS | L 5-7 |
| Fri, Mar 6 | @ |   Anaheim Ducks | TSN2, RDS | OTL 5-6 (SO) |
| Sat, Mar 7 | @ | Los Angeles Kings | SNE, TVAS, CITY | W 4-3 |
| Tue, Mar 10 | vs | Toronto Maple Leafs | SN, RDS | W 3-1 |
| Wed, Mar 11 | @ | Ottawa Senators | SN, RDS | W 3-2 |
| Sat, Mar 14 | vs | San Jose Sharks | SNE, TVAS, CITY | L 2-4 |
| Sun, Mar 15 | vs | Anaheim Ducks | TSN2, RDS | L 3-4 |
| Tue, Mar 17 | vs | Boston Bruins | TSN2, RDS | W 3-2 (OT) |
| Thu, Mar 19 | @ | Detroit Red Wings | TSN2, RDS | L 1-3 |
| Sat, Mar 21 | vs | New York Islanders | SNE, TVAS, CITY | W 7-3 |
| Tue, Mar 24 | vs | Carolina Hurricanes | TSN2, RDS | W 5-2 |
| Thu, Mar 26 | vs | Columbus Blue Jackets | TSN2, RDS | W 2-1 |
| Sat, Mar 28 | @ | Nashville Predators | SNE, TVAS, CITY | W 4-1 |
| Sun, Mar 29 | @ | Carolina Hurricanes | TSN2, RDS | W 3-1 |
| Tue, Mar 31 | @ | Tampa Bay Lightning | TSN2, RDS | W 4-1 |
| Thu, Apr 2 | @ | New York Rangers | TSN2, RDS | W 3-2 |
| Sat, Apr 4 | @ | New Jersey Devils | SNE, TVAS, CITY · NHLN(US) | W 4-3 (SO) |
| Sun, Apr 5 | vs | New Jersey Devils | TSN2, RDS | L 0-3 |
| Tue, Apr 7 | vs | Florida Panthers | TSN2, RDS | W 4-3 (SO) |
| Thu, Apr 9 | vs | Tampa Bay Lightning | TSN2, RDS | W 2-1 |
| Sat, Apr 11 | vs | Columbus Blue Jackets | SNE, TVAS, CITY | L 2-5 |
| Sun, Apr 12 | @ | New York Islanders | TSN2, RDS | W 4-1 |
| Tue, Apr 14 | @ | Philadelphia Flyers | TSN2, RDS | L 2-4 |
| Sun, Apr 19 | @ | Tampa Bay Lightning | CBC, SN, TVAS · TNT, truTV, HBO MAX(US) | W 4-3 (OT) |
| Tue, Apr 21 | @ | Tampa Bay Lightning | CBC, SN, TVAS · ESPN2(US) | OTL 2-3 (OT) |
| Fri, Apr 24 | vs | Tampa Bay Lightning | CBC, SN, TVAS · TNT, truTV, HBO MAX(US) | W 3-2 (OT) |
| Sun, Apr 26 | vs | Tampa Bay Lightning | SN, CBC, TVAS · ESPN(US) | L 2-3 |
| Wed, Apr 29 | @ | Tampa Bay Lightning | CBC, SN, TVAS · ESPN2(US) | W 3-2 |
| Fri, May 1 | vs | Tampa Bay Lightning | CBC, SN, TVAS · ESPN2(US) | OTL 0-1 (OT) |
| Sun, May 3 | @ | Tampa Bay Lightning | CBC, SN, TVAS · TNT, truTV, HBO MAX(US) | W 2-1 |
| Wed, May 6 | @ | Buffalo Sabres | CBC, SN, TVAS · TNT, truTV, HBO MAX(US) | L 2-4 |
| Fri, May 8 | @ | Buffalo Sabres | CBC, SN, TVAS · TNT, HBO MAX(US) | W 5-1 |
| Sun, May 10 | vs | Buffalo Sabres | CBC, SN, TVAS · ESPN(US) | W 6-2 |
| Tue, May 12 | vs | Buffalo Sabres | CBC, SN, TVAS · ESPN(US) | L 2-3 |
| Thu, May 14 | @ | Buffalo Sabres | CBC, SN, TVAS · TNT, truTV, HBO MAX(US) | W 6-3 |
| Sat, May 16 | vs | Buffalo Sabres | CBC, SN, TVAS · ABC(US) | L 3-8 |
| Mon, May 18 | @ | Buffalo Sabres | CBC, SN, TVAS · ESPN(US) | W 3-2 (OT) |
| Thu, May 21 | @ | Carolina Hurricanes | CBC, SN, TVAS · TNT, truTV, HBO MAX(US) | W 6-2 |
| Sat, May 23 | @ | Carolina Hurricanes | CBC, SN, TVAS · TNT, truTV, HBO MAX(US) | OTL 2-3 (OT) |
| Mon, May 25 | vs | Carolina Hurricanes | CBC, SN, TVAS · TNT, truTV, HBO MAX(US) | OTL 2-3 (OT) |
| Wed, May 27 | vs | Carolina Hurricanes | CBC, SN, TVAS · TNT, truTV, HBO MAX(US) | L 0-4 |
| Fri, May 29 | @ | Carolina Hurricanes | CBC, SN, TVAS · TNT, truTV, HBO MAX(US) | L 1-6 |
