| Wed, Oct 11 | @ |   Toronto Maple Leafs | SN, TVAS | OTL 5-6 (SO) |
| Sat, Oct 14 | vs |   Chicago Blackhawks | SNE, SN360, TVAS, CITY · NHLN(US) | W 3-2 |
| Tue, Oct 17 | vs |   Minnesota Wild | TSN2, RDS | L 2-5 |
| Sat, Oct 21 | vs |   Washington Capitals | SNE, TVAS, CITY | W 3-2 (OT) |
| Mon, Oct 23 | @ |   Buffalo Sabres | SN, RDS · NHLN(US) | W 3-1 |
| Tue, Oct 24 | vs |   New Jersey Devils | TSN2, RDS | L 2-5 |
| Thu, Oct 26 | vs |   Columbus Blue Jackets | TSN2, RDS | W 4-3 (OT) |
| Sat, Oct 28 | vs |   Winnipeg Jets | TVAS, CITY | W 4-3 (SO) |
| Mon, Oct 30 | @ |   Vegas Golden Knights | TSN2, RDS | OTL 2-3 (SO) |
| Thu, Nov 2 | @ |   ARI | TSN2, RDS | L 2-3 |
| Sat, Nov 4 | @ |   St. Louis Blues | SNE, TVAS, CITY | L 3-6 |
| Tue, Nov 7 | vs |   Tampa Bay Lightning | TSN2, RDS | L 3-5 |
| Thu, Nov 9 | @ |   Detroit Red Wings | TSN2, RDS | W 3-2 (OT) |
| Sat, Nov 11 | vs |   Boston Bruins | CBC, TVAS, CITY · NHLN(US) | W 3-2 (OT) |
| Sun, Nov 12 | vs |   Vancouver Canucks | TSN2, RDS, SNP | L 2-5 |
| Tue, Nov 14 | vs |   Calgary Flames | TSN2, RDS, SNW | L 1-2 |
| Thu, Nov 16 | vs | Vegas Golden Knights | TSN2, RDS | L 5-6 |
| Sat, Nov 18 | @ | Boston Bruins | SN, CBC, TVAS | L 2-5 |
| Wed, Nov 22 | @ |   Anaheim Ducks | TSN2, RDS | W 4-3 |
| Fri, Nov 24 | @ |   San Jose Sharks | TSN2, RDS | W 3-2 (SO) |
| Sat, Nov 25 | @ |   Los Angeles Kings | TSN2, RDS | L 0-4 |
| Wed, Nov 29 | @ | Columbus Blue Jackets | SN, RDS | W 4-2 |
| Thu, Nov 30 | vs |   Florida Panthers | TSN2, RDS | L 1-5 |
| Sat, Dec 2 | vs | Detroit Red Wings | CBC, TVAS, CITY | OTL 4-5 (OT) |
| Mon, Dec 4 | vs |   Seattle Kraken | SN, SN1, RDS | W 4-2 |
| Thu, Dec 7 | vs | Los Angeles Kings | TSN2, RDS | L 0-4 |
| Sat, Dec 9 | @ | Buffalo Sabres | CBC, SN360, TVAS | W 3-2 (SO) |
| Sun, Dec 10 | vs |   Nashville Predators | TSN2, RDS | L 1-2 |
| Wed, Dec 13 | vs |   Pittsburgh Penguins | SN, RDS | OTL 3-4 (SO) |
| Sat, Dec 16 | vs |   New York Islanders | SNE, TVAS, CITY | W 5-3 |
| Mon, Dec 18 | @ | Winnipeg Jets | SN, RDS | W 3-2 (OT) |
| Thu, Dec 21 | @ | Minnesota Wild | TSN2, RDS | OTL 3-4 (OT) |
| Fri, Dec 22 | @ | Chicago Blackhawks | TSN2, RDS | W 5-2 |
| Thu, Dec 28 | @ |   Carolina Hurricanes | TSN2, RDS | L 3-5 |
| Sat, Dec 30 | @ | Florida Panthers | SNE, TVAS, CITY | L 1-4 |
| Sun, Dec 31 | @ | Tampa Bay Lightning | TSN2, RDS | L 3-4 |
| Tue, Jan 2 | @ |   Dallas Stars | TSN2, RDS | W 4-3 |
| Thu, Jan 4 | vs | Buffalo Sabres | TSN2, RDS | L 1-6 |
| Sat, Jan 6 | vs |   New York Rangers | SNE, TVAS, CITY · NHLN(US) | W 4-3 (SO) |
| Wed, Jan 10 | @ |   Philadelphia Flyers | SN, RDS | OTL 2-3 (SO) |
| Thu, Jan 11 | vs | San Jose Sharks | TSN2, RDS | L 2-3 |
| Sat, Jan 13 | vs |   Edmonton Oilers | CBC, SN1, TVAS | OTL 1-2 (OT) |
| Mon, Jan 15 | vs |   Colorado Avalanche | SN, RDS | W 4-3 |
| Wed, Jan 17 | @ | New Jersey Devils | SN, RDS | W 3-2 |
| Thu, Jan 18 | @ |   Ottawa Senators | TSN2, RDS, TSN5 | L 2-6 |
| Sat, Jan 20 | @ | Boston Bruins | CBC, TVAS, CITY · NHLN(US) | L 4-9 |
| Tue, Jan 23 | vs | Ottawa Senators | TSN2, RDS, TSN5 | L 1-4 |
| Thu, Jan 25 | vs | New York Islanders | TSN2, RDS | W 4-3 |
| Sat, Jan 27 | @ | Pittsburgh Penguins | CBC, TVAS, CITY | OTL 2-3 (OT) |
| Tue, Feb 6 | @ | Washington Capitals | TSN2, RDS | W 5-2 |
| Sat, Feb 10 | vs | Dallas Stars | TSN2, RDS | L 2-3 |
| Sun, Feb 11 | vs | St. Louis Blues | TSN2, RDS | L 2-7 |
| Tue, Feb 13 | vs | Anaheim Ducks | TSN2, RDS | W 5-0 |
| Thu, Feb 15 | @ | New York Rangers | TSN2, RDS | L 4-7 |
| Sat, Feb 17 | vs | Washington Capitals | SNE, TVAS, CITY | L 3-4 |
| Wed, Feb 21 | vs | Buffalo Sabres | SN, RDS | L 2-3 |
| Thu, Feb 22 | @ | Pittsburgh Penguins | TSN2, RDS | L 1-4 |
| Sat, Feb 24 | @ | New Jersey Devils | TSN2, RDS | L 3-4 |
| Tue, Feb 27 | vs | ARI | TSN2, RDS | W 4-2 |
| Thu, Feb 29 | @ | Florida Panthers | TSN2, RDS | OTL 3-4 (SO) |
| Sat, Mar 2 | @ | Tampa Bay Lightning | CBC, TVAS, CITY | OTL 3-4 (SO) |
| Tue, Mar 5 | @ | Nashville Predators | TSN2, RDS | W 4-3 (OT) |
| Thu, Mar 7 | @ | Carolina Hurricanes | TSN2, RDS | L 1-4 |
| Sat, Mar 9 | vs | Toronto Maple Leafs | CBC, SN, TVAS · NHLN(US) | L 2-3 |
| Tue, Mar 12 | vs | Columbus Blue Jackets | TSN2, RDS | W 3-0 |
| Thu, Mar 14 | vs | Boston Bruins | TSN2, RDS | OTL 1-2 (OT) |
| Sat, Mar 16 | @ | Calgary Flames | CBC, TVAS, CITY | L 2-5 |
| Tue, Mar 19 | @ | Edmonton Oilers | TSN2, RDS, SNW | OTL 2-3 (OT) |
| Thu, Mar 21 | @ | Vancouver Canucks | TSN2, RDS, SNP | L 1-4 |
| Sun, Mar 24 | @ | Seattle Kraken | TSN2, RDS | W 5-1 |
| Tue, Mar 26 | @ | Colorado Avalanche | TSN2, RDS | W 2-1 |
| Thu, Mar 28 | vs | Philadelphia Flyers | TSN2, RDS | W 4-1 |
| Sat, Mar 30 | vs | Carolina Hurricanes | TVAS, CITY | L 0-3 |
| Tue, Apr 2 | vs | Florida Panthers | TSN2, RDS | W 5-3 |
| Thu, Apr 4 | vs | Tampa Bay Lightning | TSN2, RDS | L 4-7 |
| Sat, Apr 6 | vs | Toronto Maple Leafs | CBC, SN, TVAS | L 2-4 |
| Sun, Apr 7 | @ | New York Rangers | TSN2, RDS | L 2-5 |
| Tue, Apr 9 | vs | Philadelphia Flyers | TSN2, RDS | W 9-3 |
| Thu, Apr 11 | @ | New York Islanders | TSN2, RDS | OTL 2-3 (OT) |
| Sat, Apr 13 | @ | Ottawa Senators | SNE, TVAS, CITY | OTL 4-5 (SO) |
| Mon, Apr 15 | @ | Detroit Red Wings | SN, RDS | OTL 4-5 (OT) |
| Tue, Apr 16 | vs | Detroit Red Wings | TSN2, RDS | OTL 4-5 (SO) |
