| Thu, Oct 9 | @ |   Florida Panthers | | L 1-2 |
| Sat, Oct 11 | @ |   Carolina Hurricanes | | OTL 3-4 (OT) |
| Mon, Oct 13 | vs | Florida Panthers | TVAS | W 5-2 |
| Thu, Oct 16 | vs |   Winnipeg Jets | TSN3 | L 2-5 |
| Sat, Oct 18 | vs |   Minnesota Wild | | W 2-1 (OT) |
| Mon, Oct 20 | vs |   Seattle Kraken | | W 5-2 |
| Thu, Oct 23 | @ |   Ottawa Senators | TSN5, RDS2 | L 1-2 |
| Sat, Oct 25 | vs |   New York Islanders | SN | W 4-3 (SO) |
| Tue, Oct 28 | vs |   Pittsburgh Penguins | ESPN · SN1, TVAS2(CA) | W 3-2 (SO) |
| Thu, Oct 30 | vs |   Nashville Predators | | W 4-1 |
| Sat, Nov 1 | vs |   Toronto Maple Leafs | CBC · NHLN(US) | L 2-5 |
| Sun, Nov 2 | vs |   Calgary Flames | SN, TVAS · NHLN(US) | L 1-2 |
| Tue, Nov 4 | @ |   Montreal Canadiens | TSN2, RDS | W 5-4 (SO) |
| Thu, Nov 6 | @ | Nashville Predators | | W 3-1 |
| Sat, Nov 8 | vs | Ottawa Senators | TSN5, RDS2 | OTL 2-3 (OT) |
| Wed, Nov 12 | vs |   Edmonton Oilers | SN, TVAS2 | OTL 1-2 (OT) |
| Fri, Nov 14 | @ |   St. Louis Blues | | W 6-5 (SO) |
| Sat, Nov 15 | @ |   Dallas Stars | | L 1-5 |
| Thu, Nov 20 | vs | St. Louis Blues | | W 3-2 (OT) |
| Sat, Nov 22 | vs |   New Jersey Devils | | W 6-3 |
| Mon, Nov 24 | @ |   Tampa Bay Lightning | TVAS | L 0-3 |
| Wed, Nov 26 | @ | Florida Panthers | | W 4-2 |
| Fri, Nov 28 | @ | New York Islanders | | W 4-3 (SO) |
| Sat, Nov 29 | @ | New Jersey Devils | | W 5-3 |
| Mon, Dec 1 | vs | Pittsburgh Penguins | NHLN · TVAS(CA) | L 1-5 |
| Wed, Dec 3 | vs |   Buffalo Sabres | HBO MAX, TNT | W 5-2 |
| Sun, Dec 7 | vs |   Colorado Avalanche | NHLN · SN, TVAS(CA) | L 2-3 |
| Tue, Dec 9 | vs |   San Jose Sharks | | W 4-1 |
| Thu, Dec 11 | vs |   Vegas Golden Knights | ESPN · SN(CA) | OTL 2-3 (OT) |
| Sat, Dec 13 | vs | Carolina Hurricanes | | OTL 3-4 (SO) |
| Sun, Dec 14 | @ | Carolina Hurricanes | | OTL 2-3 (SO) |
| Tue, Dec 16 | @ | Montreal Canadiens | TSN2, RDS | W 4-1 |
| Thu, Dec 18 | @ | Buffalo Sabres | ESPN+, HULU | L 3-5 |
| Sat, Dec 20 | @ |   New York Rangers | | OTL 4-5 (SO) |
| Mon, Dec 22 | vs |   Vancouver Canucks | Prime, TVAS2 · NHLN(US) | W 5-2 |
| Tue, Dec 23 | @ |   Chicago Blackhawks | HBO MAX, TNT, truTV | W 3-1 |
| Sun, Dec 28 | @ | Seattle Kraken | NHLN | L 1-4 |
| Tue, Dec 30 | @ | Vancouver Canucks | SN | W 6-3 |
| Wed, Dec 31 | @ | Calgary Flames | SN1 | L 1-5 |
| Sat, Jan 3 | @ | Edmonton Oilers | SN | W 5-2 |
| Tue, Jan 6 | vs |   Anaheim Ducks | | W 5-2 |
| Thu, Jan 8 | vs | Toronto Maple Leafs | TVAS, TSN4 | OTL 1-2 (OT) |
| Sat, Jan 10 | vs | Tampa Bay Lightning | | L 2-7 |
| Mon, Jan 12 | vs | Tampa Bay Lightning | | L 1-5 |
| Wed, Jan 14 | @ | Buffalo Sabres | HBO MAX, TNT, truTV · TVAS(CA) | L 2-5 |
| Thu, Jan 15 | @ | Pittsburgh Penguins | ESPN · SN(CA) | L 3-6 |
| Sat, Jan 17 | vs | New York Rangers | | L 3-6 |
| Mon, Jan 19 | @ | Vegas Golden Knights | | W 2-1 |
| Wed, Jan 21 | @ |   Utah Mammoth | | OTL 4-5 (OT) |
| Fri, Jan 23 | @ | Colorado Avalanche | | W 7-3 |
| Mon, Jan 26 | vs | New York Islanders | | L 0-4 |
| Wed, Jan 28 | @ |   Columbus Blue Jackets | HBO MAX, TNT, truTV | L 3-5 |
| Thu, Jan 29 | @ |   Boston Bruins | SNE | L 3-6 |
| Sat, Jan 31 | vs |   Los Angeles Kings | SN1 | OTL 2-3 (OT) |
| Tue, Feb 3 | vs |   Washington Capitals | | W 4-2 |
| Thu, Feb 5 | vs | Ottawa Senators | TSN5, RDS | OTL 1-2 (OT) |
| Wed, Feb 25 | @ | Washington Capitals | | L 1-3 |
| Thu, Feb 26 | @ | New York Rangers | ESPN | W 3-2 (OT) |
| Sat, Feb 28 | vs | Boston Bruins | ABC · TVAS(CA) | W 3-1 |
| Mon, Mar 2 | @ | Toronto Maple Leafs | Prime, TVAS | W 3-2 (SO) |
| Thu, Mar 5 | vs | Utah Mammoth | | L 0-3 |
| Sat, Mar 7 | @ | Pittsburgh Penguins | | W 4-3 (SO) |
| Mon, Mar 9 | vs | New York Rangers | TVAS | L 2-6 |
| Wed, Mar 11 | vs | Washington Capitals | HBO MAX, TNT, truTV | W 4-1 |
| Thu, Mar 12 | @ | Minnesota Wild | | W 3-2 (SO) |
| Sat, Mar 14 | vs | Columbus Blue Jackets | | OTL 1-2 (SO) |
| Wed, Mar 18 | @ | Anaheim Ducks | | W 3-2 (OT) |
| Thu, Mar 19 | @ | Los Angeles Kings | | W 4-3 (SO) |
| Sat, Mar 21 | @ | San Jose Sharks | | W 4-1 |
| Tue, Mar 24 | vs | Columbus Blue Jackets | ESPN+, HULU | L 2-3 |
| Thu, Mar 26 | vs | Chicago Blackhawks | | W 5-1 |
| Sat, Mar 28 | @ |   Detroit Red Wings | ABC | W 5-3 |
| Sun, Mar 29 | vs | Dallas Stars | | W 2-1 (OT) |
| Tue, Mar 31 | @ | Washington Capitals | | L 4-6 |
| Thu, Apr 2 | vs | Detroit Red Wings | | L 2-4 |
| Fri, Apr 3 | @ | New York Islanders | NHLN · SN, TVAS(CA) | W 4-1 |
| Sun, Apr 5 | vs | Boston Bruins | HBO MAX, TNT, truTV · SN360(CA) | W 2-1 (OT) |
| Tue, Apr 7 | @ | New Jersey Devils | ESPN | W 5-1 |
| Thu, Apr 9 | @ | Detroit Red Wings | SNE | L 3-6 |
| Sat, Apr 11 | @ | Winnipeg Jets | SN1 | W 7-1 |
| Mon, Apr 13 | vs | Carolina Hurricanes | | W 3-2 (SO) |
| Tue, Apr 14 | vs | Montreal Canadiens | TSN2, RDS | W 4-2 |
| Sat, Apr 18 | @ | Pittsburgh Penguins | ESPN · SN, TVAS(CA) | W 3-2 |
| Mon, Apr 20 | @ | Pittsburgh Penguins | ESPN · SN360, TVAS2(CA) | W 3-0 |
| Wed, Apr 22 | vs | Pittsburgh Penguins | HBO MAX, TNT, truTV · SN, SN360, TVAS(CA) | W 5-2 |
| Sat, Apr 25 | vs | Pittsburgh Penguins | HBO MAX, TBS, truTV · SN, TVAS(CA) | L 2-4 |
| Mon, Apr 27 | @ | Pittsburgh Penguins | ESPN · SN, SN360, TVAS(CA) | L 2-3 |
| Wed, Apr 29 | vs | Pittsburgh Penguins | HBO MAX, TNT, truTV · SN360, TVAS(CA) | W 1-0 (OT) |
| Sat, May 2 | @ | Carolina Hurricanes | ABC · SN, TVAS(CA) | L 0-3 |
| Mon, May 4 | @ | Carolina Hurricanes | ESPN · CBC, SN, TVAS(CA) | OTL 2-3 (OT) |
| Thu, May 7 | vs | Carolina Hurricanes | HBO MAX, TNT, truTV · CBC, SN, TVAS(CA) | L 1-4 |
| Sat, May 9 | vs | Carolina Hurricanes | HBO MAX, TNT, truTV · CBC, SN, TVAS(CA) | OTL 2-3 (OT) |
