| Fri, Oct 11 | @ |   Vancouver Canucks | SNP | W 3-2 (SO) |
| Sat, Oct 12 | @ |   Calgary Flames | SNW, SN1, CITY · SN360 (JIP)(US) | L 3-6 |
| Tue, Oct 15 | @ |   Edmonton Oilers | SN1, TVAS · ESPN(US) | OTL 3-4 (OT) |
| Thu, Oct 17 | @ |   Seattle Kraken | | L 4-6 |
| Sat, Oct 19 | vs | Vancouver Canucks | SNP | L 0-3 |
| Tue, Oct 22 | vs |   Washington Capitals | ESPN+, ESPN · SN, SN1(CA) | L 1-4 |
| Wed, Oct 23 | @ | Washington Capitals | TNT, truTV, MAX · SN1, TVAS(CA) | L 3-6 |
| Sat, Oct 26 | vs |   Minnesota Wild | | W 7-5 |
| Sun, Oct 27 | vs |   Montreal Canadiens | TSN2, RDS | L 3-4 |
| Tue, Oct 29 | @ |   Boston Bruins | SN1 | W 2-0 |
| Thu, Oct 31 | vs |   St. Louis Blues | | W 2-1 |
| Sat, Nov 2 | vs | Boston Bruins | SN | L 0-3 |
| Tue, Nov 5 | @ |   Carolina Hurricanes | SN | L 4-6 |
| Thu, Nov 7 | @ |   Tampa Bay Lightning | ESPN+, HULU | W 2-1 (SO) |
| Sat, Nov 9 | @ |   Florida Panthers | | OTL 3-4 (SO) |
| Mon, Nov 11 | vs |   San Jose Sharks | | W 4-3 (SO) |
| Thu, Nov 14 | @ |   Ottawa Senators | TSN5, RDS2 | W 5-4 (OT) |
| Sat, Nov 16 | vs |   Buffalo Sabres | | W 5-2 |
| Mon, Nov 18 | vs |   Colorado Avalanche | NHLN | L 2-3 |
| Wed, Nov 20 | vs | Carolina Hurricanes | TNT, MAX | L 1-4 |
| Sat, Nov 23 | vs |   Chicago Blackhawks | NHLN · SN(CA) | W 3-2 (OT) |
| Mon, Nov 25 | vs |   Vegas Golden Knights | | OTL 4-5 (SO) |
| Wed, Nov 27 | @ |   Nashville Predators | | W 3-2 (OT) |
| Fri, Nov 29 | vs |   New York Rangers | | W 3-1 |
| Sat, Nov 30 | @ | St. Louis Blues | | W 3-2 (OT) |
| Thu, Dec 5 | vs | Florida Panthers | SNP | L 5-7 |
| Sat, Dec 7 | @ | Boston Bruins | NHLN · SN(CA) | OTL 3-4 (OT) |
| Sun, Dec 8 | vs |   Utah Mammoth | | L 2-4 |
| Tue, Dec 10 | @ |   Columbus Blue Jackets | | W 5-3 |
| Thu, Dec 12 | vs |   Detroit Red Wings | SNP | W 4-1 |
| Sat, Dec 14 | @ | Minnesota Wild | | L 1-4 |
| Wed, Dec 18 | @ | Detroit Red Wings | TNT, truTV, MAX | L 4-6 |
| Thu, Dec 19 | vs |   Los Angeles Kings | ESPN+, HULU | L 3-7 |
| Sat, Dec 21 | vs | Columbus Blue Jackets | | W 5-4 (OT) |
| Mon, Dec 23 | @ |   Pittsburgh Penguins | | L 3-7 |
| Sat, Dec 28 | @ |   Anaheim Ducks | | W 3-1 |
| Sun, Dec 29 | @ | Los Angeles Kings | SN1 | L 4-5 |
| Tue, Dec 31 | @ | San Jose Sharks | | W 4-0 |
| Thu, Jan 2 | @ | Vegas Golden Knights | SN, SN360, TVAS | L 2-5 |
| Sun, Jan 5 | @ |   Toronto Maple Leafs | SNO | OTL 2-3 (OT) |
| Tue, Jan 7 | vs | Toronto Maple Leafs | SNO · ESPN+, HULU(US) | L 2-3 |
| Thu, Jan 9 | vs |   Dallas Stars | | L 1-4 |
| Sat, Jan 11 | vs | Anaheim Ducks | | W 6-0 |
| Mon, Jan 13 | vs | Florida Panthers | TVAS | W 4-3 |
| Tue, Jan 14 | @ | Columbus Blue Jackets | | OTL 2-3 (SO) |
| Thu, Jan 16 | @ |   New York Islanders | | W 5-3 |
| Sat, Jan 18 | @ |   New Jersey Devils | NHLN | W 3-1 |
| Tue, Jan 21 | vs | Detroit Red Wings | SN1 | W 2-1 (OT) |
| Thu, Jan 23 | @ | New York Rangers | SN | L 1-6 |
| Fri, Jan 24 | @ | New York Islanders | | L 1-3 |
| Mon, Jan 27 | vs | New Jersey Devils | TVAS | W 4-2 |
| Wed, Jan 29 | @ | New Jersey Devils | TNT, truTV, MAX | L 0-5 |
| Thu, Jan 30 | vs | New York Islanders | ESPN+, HULU | L 0-3 |
| Sun, Feb 2 | @ | Colorado Avalanche | SN1 | L 0-2 |
| Tue, Feb 4 | @ | Utah Mammoth | | OTL 2-3 (OT) |
| Thu, Feb 6 | vs | Washington Capitals | SN, TVAS | L 3-4 |
| Sat, Feb 8 | vs | Pittsburgh Penguins | | W 3-2 |
| Sat, Feb 22 | vs | Edmonton Oilers | SNW, SN1 | W 6-3 |
| Tue, Feb 25 | vs | Pittsburgh Penguins | | W 6-1 |
| Thu, Feb 27 | @ | Pittsburgh Penguins | ESPN+, HULU, Disney+ | OTL 4-5 (OT) |
| Sat, Mar 1 | @ |   Winnipeg Jets | SNW | W 2-1 (SO) |
| Tue, Mar 4 | vs | Calgary Flames | SNW | L 3-6 |
| Thu, Mar 6 | vs | Winnipeg Jets | TSN3 | L 1-4 |
| Sat, Mar 8 | vs | Seattle Kraken | ESPN+, ABC · SN1(CA) | L 1-4 |
| Sun, Mar 9 | vs | New Jersey Devils | TNT, truTV, MAX · TVAS(CA) | L 1-3 |
| Tue, Mar 11 | vs | Ottawa Senators | TSN5, RDS | L 2-5 |
| Thu, Mar 13 | vs | Tampa Bay Lightning | | W 4-3 (SO) |
| Sat, Mar 15 | vs | Carolina Hurricanes | | L 0-5 |
| Mon, Mar 17 | @ | Tampa Bay Lightning | | L 0-2 |
| Thu, Mar 20 | @ | Washington Capitals | SNE | L 2-3 |
| Sat, Mar 22 | @ | Dallas Stars | | OTL 2-3 (OT) |
| Sun, Mar 23 | @ | Chicago Blackhawks | NHLN · SN1(CA) | L 4-7 |
| Tue, Mar 25 | @ | Toronto Maple Leafs | TSN4 | L 2-7 |
| Thu, Mar 27 | vs | Montreal Canadiens | TSN2, RDS | W 6-4 |
| Sat, Mar 29 | vs | Buffalo Sabres | NHLN | W 7-4 |
| Mon, Mar 31 | vs | Nashville Predators | | W 2-1 |
| Sat, Apr 5 | @ | Montreal Canadiens | SNE, TVAS, CITY | L 2-3 |
| Wed, Apr 9 | @ | New York Rangers | TNT, truTV, MAX · TVAS(CA) | W 8-5 |
| Sat, Apr 12 | vs | New York Islanders | | W 4-3 (SO) |
| Sun, Apr 13 | @ | Ottawa Senators | TSN5, RDS2 | OTL 3-4 (OT) |
| Tue, Apr 15 | vs | Columbus Blue Jackets | | L 0-3 |
| Thu, Apr 17 | @ | Buffalo Sabres | | L 4-5 |
