| Thu, Oct 9 | vs |   Montreal Canadiens | ESPN+, FDSNDET | L 1-5 |
| Sat, Oct 11 | vs |   Toronto Maple Leafs | ESPN+, FDSNDET | W 6-3 |
| Mon, Oct 13 | @ | Toronto Maple Leafs | ESPN+, FDSNDET | W 3-2 |
| Wed, Oct 15 | vs |   Florida Panthers | HBO MAX, TNT, truTV | W 4-1 |
| Fri, Oct 17 | vs |   Tampa Bay Lightning | ESPN+, FDSNDET, The Spot | W 2-1 (OT) |
| Sun, Oct 19 | vs |   Edmonton Oilers | ESPN+, FDSNDET | W 4-2 |
| Wed, Oct 22 | @ |   Buffalo Sabres | HBO MAX, TNT, truTV, FDSNDETX | L 2-4 |
| Thu, Oct 23 | @ |   New York Islanders | ESPN+, FDSNDET, MSGSN | L 2-7 |
| Sat, Oct 25 | vs |   St. Louis Blues | ESPN+, FDSNDET, FDSNMW | W 6-4 |
| Tue, Oct 28 | @ | St. Louis Blues | ESPN+, FDSNDET, FDSNMW | W 5-2 |
| Thu, Oct 30 | @ |   Los Angeles Kings | ESPN+, FDSNDET, FDSNW | W 4-3 (SO) |
| Fri, Oct 31 | @ |   Anaheim Ducks | ESPN+, Victory+, FDSNDET, KCOP-13 | L 2-5 |
| Sun, Nov 2 | @ |   San Jose Sharks | ESPN+, FDSNDET, NBCSCA | W 3-2 (SO) |
| Tue, Nov 4 | @ |   Vegas Golden Knights | ESPN+, FDSNDET, SCRIPPS | L 0-1 |
| Fri, Nov 7 | vs |   New York Rangers | NHLN, FDSNDETX, MSG | L 1-4 |
| Sun, Nov 9 | vs |   Chicago Blackhawks | NHLN, FDSNDET, CHSN | L 1-5 |
| Thu, Nov 13 | vs | Anaheim Ducks | ESPN+, Victory+, FDSNDET, KTTV | W 6-3 |
| Sat, Nov 15 | vs | Buffalo Sabres | ESPN+, FDSNDET, MSG-B | OTL 4-5 (OT) |
| Sun, Nov 16 | @ | New York Rangers | NHLN, FDSNDET, MSG | W 2-1 |
| Tue, Nov 18 | vs |   Seattle Kraken | ESPN+, FDSNDETX, KHN/Prime, KONG | W 4-2 |
| Thu, Nov 20 | vs | New York Islanders | ESPN+, FDSNDET, MSGSN2 | L 0-5 |
| Sat, Nov 22 | vs |   Columbus Blue Jackets | NHLN, FDSNDET, FDSNOH | W 4-3 (OT) |
| Mon, Nov 24 | @ |   New Jersey Devils | ESPN+, FDSNDETX, MSGSN | L 3-4 |
| Wed, Nov 26 | vs |   Nashville Predators | ESPN+, FDSNDETX, FDSNSO | L 3-6 |
| Fri, Nov 28 | vs | Tampa Bay Lightning | ESPN+, FDSNDET, The Spot | L 3-6 |
| Sat, Nov 29 | @ |   Boston Bruins | ESPN+, FDSNDET, NESN | OTL 2-3 (SO) |
| Tue, Dec 2 | vs | Boston Bruins | ESPN+, FDSNDET, NESN | W 5-4 |
| Thu, Dec 4 | @ | Columbus Blue Jackets | ESPN+, HULU | OTL 5-6 (SO) |
| Sat, Dec 6 | @ | Seattle Kraken | ESPN+, FDSNDETX, KHN/Prime, KONG | W 4-3 |
| Mon, Dec 8 | @ |   Vancouver Canucks | ESPN+, FDSNDET | W 4-0 |
| Wed, Dec 10 | @ |   Calgary Flames | ESPN+, FDSNDET | W 4-3 |
| Thu, Dec 11 | @ | Edmonton Oilers | ESPN+, FDSNDET | L 1-4 |
| Sat, Dec 13 | @ | Chicago Blackhawks | ESPN+, FDSNDET, CHSN | W 4-0 |
| Tue, Dec 16 | vs | New York Islanders | ESPN+, FDSNDET, MSGSN | W 3-2 |
| Wed, Dec 17 | vs |   Utah Mammoth | HBO MAX, TNT, truTV | L 1-4 |
| Sat, Dec 20 | @ |   Washington Capitals | NHLN, FDSNDET, MNMT | W 5-2 |
| Sun, Dec 21 | vs | Washington Capitals | NHLN, FDSNDET, MNMT | W 3-2 (OT) |
| Tue, Dec 23 | vs |   Dallas Stars | HBO MAX, Victory+, TNT, truTV | W 4-3 (OT) |
| Sat, Dec 27 | @ |   Carolina Hurricanes | ESPN+, FDSNDET, FDSNSO | L 2-5 |
| Sun, Dec 28 | vs | Toronto Maple Leafs | ESPN+, FDSNDET | W 3-2 (OT) |
| Wed, Dec 31 | vs |   Winnipeg Jets | ESPN+, FDSNDET | W 2-1 |
| Thu, Jan 1 | @ |   Pittsburgh Penguins | ESPN+, FDSNDET, SN-PIT | OTL 3-4 (OT) |
| Sat, Jan 3 | vs | Pittsburgh Penguins | ABC | L 1-4 |
| Mon, Jan 5 | @ |   Ottawa Senators | ESPN+, FDSNDET | W 5-3 |
| Thu, Jan 8 | vs | Vancouver Canucks | ESPN+, FDSNDET | W 5-1 |
| Sat, Jan 10 | @ | Montreal Canadiens | ESPN+, FDSNDET | W 4-0 |
| Mon, Jan 12 | vs | Carolina Hurricanes | ESPN+, FDSNDET, FDSNSO | W 4-3 (OT) |
| Tue, Jan 13 | @ | Boston Bruins | HBO MAX, TNT, NESN | L 0-3 |
| Fri, Jan 16 | vs | San Jose Sharks | NHLN, FDSNDET, NBCSCA | W 4-2 |
| Sun, Jan 18 | vs | Ottawa Senators | ESPN+, FDSNDET | W 4-3 (OT) |
| Wed, Jan 21 | @ | Toronto Maple Leafs | HBO MAX, TNT, truTV | W 2-1 (OT) |
| Thu, Jan 22 | @ |   Minnesota Wild | ESPN | OTL 3-4 (OT) |
| Sat, Jan 24 | @ | Winnipeg Jets | ESPN+, FDSNDET | W 5-1 |
| Tue, Jan 27 | vs | Los Angeles Kings | ESPN+, FDSNDETX, FDSNW | L 1-3 |
| Thu, Jan 29 | vs | Washington Capitals | ESPN+, HULU | OTL 3-4 (SO) |
| Sat, Jan 31 | vs |   Colorado Avalanche | ABC | L 0-5 |
| Mon, Feb 2 | @ | Colorado Avalanche | ESPN+, FDSNDET, ALT, KTVD | W 2-0 |
| Wed, Feb 4 | @ | Utah Mammoth | ESPN+, FDSNDET, Utah16 | L 1-4 |
| Thu, Feb 26 | @ | Ottawa Senators | ESPN+, FDSNDET | W 2-1 (OT) |
| Sat, Feb 28 | @ | Carolina Hurricanes | ESPN+, FDSNDET, FDSNSO | L 2-5 |
| Mon, Mar 2 | @ | Nashville Predators | NHLN, FDSNDET, FDSNSO | W 4-2 |
| Wed, Mar 4 | vs | Vegas Golden Knights | ESPN+, FDSNDET, SCRIPPS | OTL 3-4 (OT) |
| Fri, Mar 6 | vs | Florida Panthers | NHLN, FDSNDET, SCRIPPS | L 1-3 |
| Sun, Mar 8 | @ | New Jersey Devils | ESPN | W 3-0 |
| Tue, Mar 10 | @ | Florida Panthers | ESPN+, FDSNDET, SCRIPPS | L 3-4 |
| Thu, Mar 12 | @ | Tampa Bay Lightning | ESPN+, FDSNDET, The Spot | L 1-4 |
| Sat, Mar 14 | @ | Dallas Stars | ESPN+, Victory+, FDSNDET | OTL 2-3 (OT) |
| Mon, Mar 16 | vs | Calgary Flames | ESPN+, FDSNDET | W 5-2 |
| Thu, Mar 19 | vs | Montreal Canadiens | ESPN+, FDSNDET | W 3-1 |
| Sat, Mar 21 | vs | Boston Bruins | ABC | L 2-4 |
| Tue, Mar 24 | vs | Ottawa Senators | ESPN+, FDSNDET | L 2-3 |
| Fri, Mar 27 | @ | Buffalo Sabres | NHLN, FDSNDET, MSG-B | W 5-2 |
| Sat, Mar 28 | vs |   Philadelphia Flyers | ABC | L 3-5 |
| Tue, Mar 31 | @ | Pittsburgh Penguins | ESPN+, FDSNDET, SN-PIT+ | L 1-5 |
| Thu, Apr 2 | @ | Philadelphia Flyers | ESPN+, FDSNDETX, NBCSP | W 4-2 |
| Sat, Apr 4 | @ | New York Rangers | ABC | L 1-4 |
| Sun, Apr 5 | vs | Minnesota Wild | HBO MAX, TNT, truTV | L 4-5 |
| Tue, Apr 7 | vs | Columbus Blue Jackets | ESPN+, FDSNDET, FDSNOH | OTL 3-4 (SO) |
| Thu, Apr 9 | vs | Philadelphia Flyers | ESPN+, FDSNDET, NBCSP+ | W 6-3 |
| Sat, Apr 11 | vs | New Jersey Devils | ESPN+, FDSNDET, MSGSN | L 3-5 |
| Mon, Apr 13 | @ | Tampa Bay Lightning | ESPN+, FDSNDET, The Spot | OTL 3-4 (OT) |
| Wed, Apr 15 | @ | Florida Panthers | ESPN+, FDSNDET, SCRIPPS | L 1-8 |
