| Thu, Oct 10 | vs |   Pittsburgh Penguins | ESPN+, BSDET, SN-PIT | L 3-6 |
| Sat, Oct 12 | vs |   Nashville Predators | ESPN+, BSDET, BSSO | W 3-0 |
| Mon, Oct 14 | @ |   New York Rangers | NHLN, BSDET, MSG | L 1-4 |
| Thu, Oct 17 | vs | New York Rangers | ESPN+, HULU | L 2-5 |
| Sat, Oct 19 | @ | Nashville Predators | ESPN+, BSDET, BSSO | W 5-2 |
| Tue, Oct 22 | @ |   New York Islanders | ESPN+, FDSNDET, MSGSN2 | W 1-0 |
| Thu, Oct 24 | vs |   New Jersey Devils | ESPN+, FDSNDET, MSGSN | W 5-3 |
| Sat, Oct 26 | @ |   Buffalo Sabres | ESPN+, FDSNDET, MSG-B | L 3-5 |
| Sun, Oct 27 | vs |   Edmonton Oilers | NHLN, FDSNDET | OTL 2-3 (OT) |
| Wed, Oct 30 | vs |   Winnipeg Jets | ESPN+, FDSNDET | L 2-6 |
| Sat, Nov 2 | vs | Buffalo Sabres | ESPN+, FDSNDET, MSG-B | W 2-1 |
| Wed, Nov 6 | @ |   Chicago Blackhawks | TNT, truTV, MAX | W 4-1 |
| Fri, Nov 8 | @ |   Toronto Maple Leafs | ESPN+, FDSNDET | L 1-3 |
| Sat, Nov 9 | vs | New York Rangers | ESPN+, FDSNDET, MSG | L 0-4 |
| Wed, Nov 13 | @ | Pittsburgh Penguins | TNT, MAX, SN-PIT | W 3-2 (OT) |
| Fri, Nov 15 | @ |   Anaheim Ducks | ESPN+, Victory+, FDSNDET | L 4-6 |
| Sat, Nov 16 | @ |   Los Angeles Kings | ESPN+, FDSNDET, FDSNW | L 1-4 |
| Mon, Nov 18 | @ |   San Jose Sharks | ESPN+, FDSNDET, NBCSCA | OTL 4-5 (OT) |
| Thu, Nov 21 | vs | New York Islanders | ESPN+, FDSNDET, MSGSN2 | W 2-1 |
| Sat, Nov 23 | vs |   Boston Bruins | ESPN+, FDSNDETX, NESN | L 1-2 |
| Mon, Nov 25 | @ | New York Islanders | ESPN+, FDSNDET, MSGSN2 | W 4-2 |
| Wed, Nov 27 | vs |   Calgary Flames | ESPN+, FDSNDETX | W 2-1 (OT) |
| Fri, Nov 29 | vs | New Jersey Devils | ESPN+, FDSNDET, MSGSN | L 4-5 |
| Sun, Dec 1 | vs |   Vancouver Canucks | ESPN+, FDSNDET | OTL 4-5 (OT) |
| Tue, Dec 3 | @ | Boston Bruins | ESPN+, HULU | OTL 2-3 (OT) |
| Thu, Dec 5 | @ |   Ottawa Senators | ESPN+, FDSNDET | L 1-2 |
| Sat, Dec 7 | vs |   Colorado Avalanche | ESPN+, FDSNDETX, ALT | L 1-2 |
| Mon, Dec 9 | @ | Buffalo Sabres | ESPN+, FDSNDET, MSG-B | W 6-5 (SO) |
| Thu, Dec 12 | @ |   Philadelphia Flyers | ESPN+, FDSNDET, NBCSP | L 1-4 |
| Sat, Dec 14 | vs | Toronto Maple Leafs | NHLN, FDSNDET | W 4-2 |
| Wed, Dec 18 | vs | Philadelphia Flyers | TNT, truTV, MAX | W 6-4 |
| Fri, Dec 20 | vs |   Montreal Canadiens | ESPN+, FDSNDET | L 3-4 |
| Sat, Dec 21 | @ | Montreal Canadiens | NHLN, FDSNDETX | L 1-5 |
| Mon, Dec 23 | vs |   St. Louis Blues | ESPN+, FDSNDET, FDSNMW | L 0-4 |
| Fri, Dec 27 | vs | Toronto Maple Leafs | ESPN+, FDSNDET | L 2-5 |
| Sun, Dec 29 | vs |   Washington Capitals | ESPN+, FDSNDET, MNMT | W 4-2 |
| Tue, Dec 31 | vs | Pittsburgh Penguins | ESPN+, FDSNDET, SN-PIT | W 4-2 |
| Thu, Jan 2 | @ |   Columbus Blue Jackets | ESPN+, FDSNDET, FDSNOH | W 5-4 |
| Sat, Jan 4 | @ | Winnipeg Jets | ESPN+, FDSNDET | W 4-2 |
| Tue, Jan 7 | vs | Ottawa Senators | ESPN+, FDSNDET | W 3-2 (OT) |
| Fri, Jan 10 | vs | Chicago Blackhawks | NHLN, FDSNDET, CHSN | W 5-3 |
| Sun, Jan 12 | vs |   Seattle Kraken | NHLN, FDSNDET, KHN/Prime, KONG | W 6-2 |
| Tue, Jan 14 | vs | San Jose Sharks | ESPN+, FDSNDET, NBCSCA | L 3-6 |
| Thu, Jan 16 | @ |   Florida Panthers | ESPN | W 5-2 |
| Sat, Jan 18 | @ |   Tampa Bay Lightning | ESPN+, FDSNDET, FDSNSUN | L 1-5 |
| Sun, Jan 19 | @ |   Dallas Stars | ESPN+, Victory+, FDSNDET | L 1-4 |
| Tue, Jan 21 | @ | Philadelphia Flyers | ESPN+, FDSNDET, NBCSP | OTL 1-2 (OT) |
| Thu, Jan 23 | vs | Montreal Canadiens | ESPN+, FDSNDET | W 4-2 |
| Sat, Jan 25 | vs | Tampa Bay Lightning | ESPN+, FDSNDET, FDSNSUN | W 2-0 |
| Mon, Jan 27 | vs | Los Angeles Kings | NHLN, FDSNDETX, FDSNW | W 5-2 |
| Thu, Jan 30 | @ | Edmonton Oilers | ESPN+, FDSNDET | W 3-2 (SO) |
| Sat, Feb 1 | @ | Calgary Flames | ESPN+, FDSNDET | W 3-1 |
| Sun, Feb 2 | @ | Vancouver Canucks | ESPN+, FDSNDET | W 3-2 (OT) |
| Tue, Feb 4 | @ | Seattle Kraken | ESPN+, FDSNDET, KHN/Prime, KONG | W 5-4 (SO) |
| Sat, Feb 8 | vs | Tampa Bay Lightning | ESPN+, ABC | L 3-6 |
| Sat, Feb 22 | vs |   Minnesota Wild | ESPN+, ABC | OTL 3-4 (OT) |
| Sun, Feb 23 | vs | Anaheim Ducks | ESPN+, Victory+, FDSNDETX, KCOP-13 | W 5-4 (OT) |
| Tue, Feb 25 | @ | Minnesota Wild | ESPN+, FDSNDET, FDSNNO, FDSNWIX | W 3-2 |
| Thu, Feb 27 | vs | Columbus Blue Jackets | ESPN+, FDSNDET, FDSNOH | L 2-5 |
| Sat, Mar 1 | @ | Columbus Blue Jackets | ESPN+, ESPN, Disney+ | L 3-5 |
| Tue, Mar 4 | vs |   Carolina Hurricanes | ESPN+, FDSNDET, FDSNSO | L 1-2 |
| Thu, Mar 6 | vs |   Utah Mammoth | ESPN+, FDSNDET, Utah16 | L 2-4 |
| Fri, Mar 7 | @ | Washington Capitals | ESPN+, FDSNDET, MNMT | L 2-5 |
| Mon, Mar 10 | @ | Ottawa Senators | ESPN+, FDSNDET | L 1-2 |
| Wed, Mar 12 | vs | Buffalo Sabres | TNT, truTV, MAX, FDSNDET | W 7-3 |
| Fri, Mar 14 | @ | Carolina Hurricanes | ESPN+, FDSNDET, FDSNSO | L 2-4 |
| Sun, Mar 16 | vs |   Vegas Golden Knights | TNT, truTV, MAX, SCRIPPS | W 3-0 |
| Tue, Mar 18 | @ | Washington Capitals | ESPN+, FDSNDET, MNMT | L 1-4 |
| Sat, Mar 22 | @ | Vegas Golden Knights | ESPN+, ABC | L 3-6 |
| Mon, Mar 24 | @ | Utah Mammoth | ESPN+, FDSNDET, Utah16 | W 5-1 |
| Tue, Mar 25 | @ | Colorado Avalanche | ESPN+, FDSNDET, ALT, KTVD | L 2-5 |
| Thu, Mar 27 | vs | Ottawa Senators | ESPN+, FDSNDETX | L 3-4 |
| Sat, Mar 29 | vs | Boston Bruins | ESPN+, ABC | W 2-1 |
| Tue, Apr 1 | @ | St. Louis Blues | ESPN+, FDSNDET, FDSNMW | OTL 1-2 (OT) |
| Fri, Apr 4 | vs | Carolina Hurricanes | ESPN+, FDSNDET, FDSNSO | W 5-3 |
| Sun, Apr 6 | vs | Florida Panthers | TNT, truTV, MAX | W 2-1 |
| Tue, Apr 8 | @ | Montreal Canadiens | ESPN+, FDSNDETX | L 1-4 |
| Thu, Apr 10 | @ | Florida Panthers | ESPN+, FDSNDET, SCRIPPS | L 1-4 |
| Fri, Apr 11 | @ | Tampa Bay Lightning | ESPN+, FDSNDET, FDSNFL | W 4-3 (OT) |
| Mon, Apr 14 | vs | Dallas Stars | Victory+, NHLN, FDSNDETX | W 6-4 |
| Wed, Apr 16 | @ | New Jersey Devils | TNT, truTV, MAX, FDSNDET | W 5-2 |
| Thu, Apr 17 | @ | Toronto Maple Leafs | ESPN+, FDSNDET | OTL 3-4 (OT) |
