| Fri, Oct 4 | vs |   New Jersey Devils | NHLN, MSG-B, MSGSN | L 1-4 |
| Sat, Oct 5 | @ | New Jersey Devils | NHLN, MSG-B, MSGSN | L 1-3 |
| Thu, Oct 10 | vs |   Los Angeles Kings | ESPN+, MSG-B, BSW | L 1-3 |
| Sat, Oct 12 | vs |   Florida Panthers | ESPN+, MSG-B, SCRIPPS | W 5-2 |
| Wed, Oct 16 | @ |   Pittsburgh Penguins | TNT, truTV, MAX | OTL 5-6 (OT) |
| Thu, Oct 17 | @ |   Columbus Blue Jackets | ESPN+, MSG-B, BSOH | L 4-6 |
| Sat, Oct 19 | @ |   Chicago Blackhawks | ESPN+, MSG-B, CHSN | W 4-2 |
| Tue, Oct 22 | vs |   Dallas Stars | ESPN+, Victory+, MSG-B | W 4-2 |
| Sat, Oct 26 | vs |   Detroit Red Wings | ESPN+, MSG-B, FDSNDET | W 5-3 |
| Mon, Oct 28 | vs | Florida Panthers | ESPN+, MSG-B, SCRIPPS | L 2-5 |
| Fri, Nov 1 | vs |   New York Islanders | ESPN+, MSG-B, MSGSN | L 3-4 |
| Sat, Nov 2 | @ | Detroit Red Wings | ESPN+, MSG-B, FDSNDET | L 1-2 |
| Tue, Nov 5 | vs |   Ottawa Senators | ESPN+, MSG-B | W 5-1 |
| Thu, Nov 7 | @ |   New York Rangers | ESPN+, MSG-B, MSG | W 6-1 |
| Sat, Nov 9 | vs |   Calgary Flames | ESPN+, MSG-B | W 3-2 (SO) |
| Mon, Nov 11 | vs |   Montreal Canadiens | ESPN+, MSG-B | L 5-7 |
| Thu, Nov 14 | vs |   St. Louis Blues | ESPN+, HULU | W 4-3 (OT) |
| Sat, Nov 16 | @ |   Philadelphia Flyers | ESPN+, MSG-B, NBCSP | L 2-5 |
| Wed, Nov 20 | @ | Los Angeles Kings | ESPN+, MSG-B, FDSNW | W 1-0 |
| Fri, Nov 22 | @ |   Anaheim Ducks | ESPN+, Victory+, MSG-B, KCOP-13 | W 3-2 (OT) |
| Sat, Nov 23 | @ |   San Jose Sharks | ESPN+, MSG-B, NBCSCA | W 4-2 |
| Wed, Nov 27 | vs |   Minnesota Wild | ESPN+, MSG-B, FDSNNO, FDSNWI | L 0-1 |
| Fri, Nov 29 | vs |   Vancouver Canucks | ESPN+, MSG-B | OTL 3-4 (OT) |
| Sat, Nov 30 | @ | New York Islanders | ESPN+, MSG-B, MSGSN | L 0-3 |
| Tue, Dec 3 | vs |   Colorado Avalanche | ESPN+, MSG-B, ALT, KTVD | L 4-5 |
| Thu, Dec 5 | vs |   Winnipeg Jets | ESPN+, MSG-B | OTL 2-3 (OT) |
| Sat, Dec 7 | vs |   Utah Mammoth | ESPN+, MSG-B, Utah16 | L 2-5 |
| Mon, Dec 9 | vs | Detroit Red Wings | ESPN+, MSG-B, FDSNDET | OTL 5-6 (SO) |
| Wed, Dec 11 | vs | New York Rangers | TNT, truTV, MAX | L 2-3 |
| Sat, Dec 14 | @ |   Washington Capitals | ESPN+, MSG-B, MNMT | L 2-4 |
| Sun, Dec 15 | @ |   Toronto Maple Leafs | ESPN+, MSG-B | L 3-5 |
| Tue, Dec 17 | @ | Montreal Canadiens | ESPN+, MSG-B | L 1-6 |
| Fri, Dec 20 | vs | Toronto Maple Leafs | ESPN+, HULU | L 3-6 |
| Sat, Dec 21 | @ |   Boston Bruins | ESPN+, MSG-B, NESN | L 1-3 |
| Mon, Dec 23 | @ | New York Islanders | ESPN+, MSG-B, MSGSN | W 7-1 |
| Fri, Dec 27 | vs | Chicago Blackhawks | ESPN+, ESPN2 | W 6-2 |
| Sun, Dec 29 | @ | St. Louis Blues | ESPN+, MSG-B, FDSNMW | W 4-2 |
| Tue, Dec 31 | @ | Dallas Stars | ESPN+, Victory+, MSG-B | L 2-4 |
| Thu, Jan 2 | @ | Colorado Avalanche | ESPN+, MSG-B, ALT, KTVD | OTL 5-6 (OT) |
| Sat, Jan 4 | @ |   Vegas Golden Knights | ESPN+, MSG-B, SCRIPPS | L 1-3 |
| Mon, Jan 6 | vs | Washington Capitals | NHLN, MSG-B, MNMT | W 4-3 (SO) |
| Thu, Jan 9 | @ | Ottawa Senators | ESPN+, MSG-B | W 4-0 |
| Sat, Jan 11 | vs |   Seattle Kraken | ESPN+, MSG-B, KHN/Prime, KONG | L 2-6 |
| Wed, Jan 15 | vs |   Carolina Hurricanes | TNT, truTV, MAX | W 4-2 |
| Fri, Jan 17 | vs | Pittsburgh Penguins | ESPN+, MSG-B, SN-PIT | L 2-5 |
| Mon, Jan 20 | @ | Seattle Kraken | ESPN+, MSG-B, KHN/Prime, KONG | L 4-6 |
| Tue, Jan 21 | @ | Vancouver Canucks | ESPN+, MSG-B | W 3-2 |
| Thu, Jan 23 | @ | Calgary Flames | ESPN+, MSG-B | L 2-5 |
| Sat, Jan 25 | @ |   Edmonton Oilers | ESPN+, MSG-B | L 2-3 |
| Tue, Jan 28 | vs | Boston Bruins | ESPN+, MSG-B, NESN | W 7-2 |
| Fri, Jan 31 | vs |   Nashville Predators | NHLN, MSG-B, FDSNSO | W 4-3 |
| Sun, Feb 2 | vs | New Jersey Devils | ESPN+, MSG-B, MSGSN | W 4-3 |
| Tue, Feb 4 | vs | Columbus Blue Jackets | ESPN+, MSG-B, FDSNOH | W 3-2 |
| Sat, Feb 8 | @ | Nashville Predators | ESPN+, MSG-B, FDSNSO | L 4-6 |
| Sat, Feb 22 | vs | New York Rangers | ESPN+, MSG-B, MSG | W 8-2 |
| Tue, Feb 25 | vs | Anaheim Ducks | ESPN+, Victory+, MSG-B, KCOP-13 | W 3-2 |
| Thu, Feb 27 | @ | Carolina Hurricanes | ESPN+, MSG-B, FDSNSO | L 2-5 |
| Sat, Mar 1 | vs | Montreal Canadiens | ESPN+, MSG-B | L 2-4 |
| Mon, Mar 3 | @ | Montreal Canadiens | ESPN+, MSG-B | OTL 3-4 (OT) |
| Tue, Mar 4 | vs | San Jose Sharks | ESPN+, MSG-B, NBCSCA | L 2-6 |
| Thu, Mar 6 | @ |   Tampa Bay Lightning | ESPN | L 5-6 |
| Sat, Mar 8 | @ | Florida Panthers | ESPN+, MSG-B, SCRIPPS | L 0-4 |
| Mon, Mar 10 | vs | Edmonton Oilers | ESPN+, HULU, Disney+ | W 3-2 |
| Wed, Mar 12 | @ | Detroit Red Wings | TNT, truTV, MAX, FDSNDET | L 3-7 |
| Sat, Mar 15 | vs | Vegas Golden Knights | ESPN+, MSG-B, SCRIPPS | W 4-3 (SO) |
| Mon, Mar 17 | @ | Boston Bruins | ESPN+, MSG-B, NESN | W 3-2 (OT) |
| Thu, Mar 20 | @ | Utah Mammoth | ESPN+, MSG-B, Utah16 | L 2-5 |
| Sat, Mar 22 | @ | Minnesota Wild | ESPN+, MSG-B, FDSNNO, FDSNWI | L 1-4 |
| Sun, Mar 23 | @ | Winnipeg Jets | ESPN+, MSG-B | W 5-3 |
| Tue, Mar 25 | vs | Ottawa Senators | ESPN+, MSG-B | W 3-2 |
| Thu, Mar 27 | vs | Pittsburgh Penguins | ESPN+, MSG-B, SN-PIT | W 7-3 |
| Sat, Mar 29 | @ | Philadelphia Flyers | NHLN, MSG-B, NBCSP | L 4-7 |
| Sun, Mar 30 | @ | Washington Capitals | ESPN+, MSG-B, MNMT | W 8-5 |
| Tue, Apr 1 | @ | Ottawa Senators | ESPN+, MSG-B | W 5-2 |
| Sat, Apr 5 | vs | Tampa Bay Lightning | ESPN+, MSG-B, FDSNSUN | W 3-2 (SO) |
| Sun, Apr 6 | vs | Boston Bruins | ESPN+, MSG-B, NESN | W 6-3 |
| Tue, Apr 8 | vs | Carolina Hurricanes | ESPN+, MSG-B, FDSNSO | W 3-0 |
| Thu, Apr 10 | @ | Columbus Blue Jackets | ESPN+, MSG-B, FDSNOH | L 2-3 |
| Sat, Apr 12 | @ | Florida Panthers | ESPN+, MSG-B, SCRIPPS | OTL 2-3 (SO) |
| Sun, Apr 13 | @ | Tampa Bay Lightning | ESPN+, MSG-B, FDSNSUN | L 4-7 |
| Tue, Apr 15 | vs | Toronto Maple Leafs | ESPN+, MSG-B | L 0-4 |
| Thu, Apr 17 | vs | Philadelphia Flyers | ESPN+, MSG-B, NBCSP | W 5-4 |
