| Wed, Oct 9 | vs |   New York Rangers | TNT, MAX | L 0-6 |
| Thu, Oct 10 | @ |   Detroit Red Wings | ESPN+, SN-PIT, BSDET | W 6-3 |
| Sat, Oct 12 | @ |   Toronto Maple Leafs | NHLN, SN-PIT | L 2-4 |
| Mon, Oct 14 | @ |   Montreal Canadiens | ESPN+, SN-PIT | W 6-3 |
| Wed, Oct 16 | vs |   Buffalo Sabres | TNT, truTV, MAX | W 6-5 (OT) |
| Fri, Oct 18 | vs |   Carolina Hurricanes | NHLN, SN-PIT, BSSO | L 1-4 |
| Sun, Oct 20 | @ |   Winnipeg Jets | ESPN+, SN-PIT | L 3-6 |
| Tue, Oct 22 | @ |   Calgary Flames | ESPN+, SN-PIT | OTL 3-4 (SO) |
| Fri, Oct 25 | @ |   Edmonton Oilers | ESPN+, SN-PIT | L 0-4 |
| Sat, Oct 26 | @ |   Vancouver Canucks | ESPN+, SN-PIT | L 3-4 |
| Tue, Oct 29 | vs |   Minnesota Wild | ESPN+, SN-PIT, FDSNNO, FDSNWI | L 3-5 |
| Thu, Oct 31 | vs |   Anaheim Ducks | ESPN+, Victory+, SN-PIT, KCOP-13 | W 2-1 (OT) |
| Sat, Nov 2 | vs | Montreal Canadiens | NHLN, SN-PIT | W 3-1 |
| Tue, Nov 5 | @ |   New York Islanders | ESPN+, SN-PIT, MSGSN | OTL 3-4 (SO) |
| Thu, Nov 7 | @ | Carolina Hurricanes | ESPN+, SN-PIT, FDSNSO | L 1-5 |
| Fri, Nov 8 | @ |   Washington Capitals | ESPN+, HULU | W 4-2 |
| Mon, Nov 11 | vs |   Dallas Stars | ESPN+, Victory+, SN-PIT | L 1-7 |
| Wed, Nov 13 | vs | Detroit Red Wings | TNT, MAX, SN-PIT | OTL 2-3 (OT) |
| Fri, Nov 15 | @ |   Columbus Blue Jackets | NHLN, SN-PIT, FDSNOH | L 2-6 |
| Sat, Nov 16 | vs |   San Jose Sharks | ESPN+, SN-PIT, NBCSCA | W 4-3 (SO) |
| Tue, Nov 19 | vs |   Tampa Bay Lightning | ESPN+, SN-PIT, FDSNSUN | OTL 2-3 (OT) |
| Fri, Nov 22 | vs | Winnipeg Jets | NHLN, SN-PIT | L 1-4 |
| Sat, Nov 23 | vs |   Utah Mammoth | ESPN+, SN-PIT, Utah16 | L 1-6 |
| Wed, Nov 27 | vs | Vancouver Canucks | ESPN+, SN-PIT | W 5-4 |
| Fri, Nov 29 | @ |   Boston Bruins | TNT, MAX | W 2-1 |
| Sat, Nov 30 | vs | Calgary Flames | NHLN, SN-PIT | W 6-2 |
| Tue, Dec 3 | vs |   Florida Panthers | ESPN+, SN-PIT, SCRIPPS | W 5-4 (OT) |
| Fri, Dec 6 | @ | New York Rangers | ESPN+, HULU | L 2-4 |
| Sat, Dec 7 | vs | Toronto Maple Leafs | NHLN, SN-PIT | W 5-2 |
| Tue, Dec 10 | vs |   Colorado Avalanche | ESPN+, SN-PIT, ALT | L 2-6 |
| Thu, Dec 12 | @ | Montreal Canadiens | ESPN+, SN-PIT | W 9-2 |
| Sat, Dec 14 | @ |   Ottawa Senators | ESPN+, SN-PIT | OTL 2-3 (OT) |
| Tue, Dec 17 | vs |   Los Angeles Kings | ESPN+, SN-PIT, FDSNW | W 3-2 (OT) |
| Thu, Dec 19 | @ |   Nashville Predators | ESPN+, SN-PIT, FDSNSO | W 5-4 (OT) |
| Sat, Dec 21 | @ |   New Jersey Devils | ESPN+, SN-PIT, MSGSN | L 0-3 |
| Mon, Dec 23 | vs |   Philadelphia Flyers | ESPN+, SN-PIT, NBCSP+ | W 7-3 |
| Sat, Dec 28 | @ | New York Islanders | ESPN+, SN-PIT, MSGSN | L 3-6 |
| Sun, Dec 29 | vs | New York Islanders | ESPN+, SN-PIT, MSGSN | W 3-2 |
| Tue, Dec 31 | @ | Detroit Red Wings | ESPN+, SN-PIT, FDSNDET | L 2-4 |
| Fri, Jan 3 | @ | Florida Panthers | NHLN, SN-PIT, SCRIPPS | OTL 2-3 (SO) |
| Sun, Jan 5 | @ | Carolina Hurricanes | ESPN+, SN-PIT, FDSNSO | OTL 3-4 (OT) |
| Tue, Jan 7 | vs | Columbus Blue Jackets | ESPN+, SN-PIT, FDSNOH | OTL 3-4 (SO) |
| Thu, Jan 9 | vs | Edmonton Oilers | ESPN+, SN-PIT | W 5-3 |
| Sat, Jan 11 | vs | Ottawa Senators | ESPN+, SN-PIT | L 0-5 |
| Sun, Jan 12 | vs | Tampa Bay Lightning | ESPN+, SN-PIT, FDSNSUN | L 2-5 |
| Tue, Jan 14 | vs |   Seattle Kraken | ESPN+, SN-PIT, KHN/Prime, KONG | L 2-4 |
| Fri, Jan 17 | @ | Buffalo Sabres | ESPN+, SN-PIT, MSG-B | W 5-2 |
| Sat, Jan 18 | @ | Washington Capitals | ESPN+, SN-PIT, MNMT | L 1-4 |
| Mon, Jan 20 | @ | Los Angeles Kings | ESPN+, SN-PIT, FDSNW | W 5-1 |
| Thu, Jan 23 | @ | Anaheim Ducks | ESPN+, Victory+, SN-PIT, KCOP-13 | L 1-5 |
| Sat, Jan 25 | @ | Seattle Kraken | ESPN+, SN-PIT, KHN/Prime, KONG | L 1-4 |
| Mon, Jan 27 | @ | San Jose Sharks | ESPN+, SN-PIT, NBCSCA | L 1-2 |
| Wed, Jan 29 | @ | Utah Mammoth | TNT, MAX, SN-PIT | W 3-2 (OT) |
| Sat, Feb 1 | vs | Nashville Predators | ESPN+, SN-PIT, FDSNSO | W 3-0 |
| Tue, Feb 4 | vs | New Jersey Devils | ESPN+, SN-PIT, MSGSN2 | OTL 2-3 (SO) |
| Fri, Feb 7 | @ | New York Rangers | NHLN, SN-PIT, MSG | W 3-2 |
| Sat, Feb 8 | @ | Philadelphia Flyers | ESPN+, SN-PIT, NBCSP | L 2-3 |
| Sat, Feb 22 | vs | Washington Capitals | ESPN+, ABC | L 3-8 |
| Sun, Feb 23 | vs | New York Rangers | TNT, truTV, MAX | L 3-5 |
| Tue, Feb 25 | @ | Philadelphia Flyers | ESPN+, SN-PIT, NBCSP | L 1-6 |
| Thu, Feb 27 | vs | Philadelphia Flyers | ESPN+, HULU, Disney+ | W 5-4 (OT) |
| Sat, Mar 1 | vs | Boston Bruins | ESPN+, ABC | L 2-3 |
| Sun, Mar 2 | vs | Toronto Maple Leafs | TNT, truTV, MAX | OTL 5-6 (OT) |
| Tue, Mar 4 | @ | Colorado Avalanche | ESPN+, SN-PIT, ALT | L 1-4 |
| Fri, Mar 7 | @ |   Vegas Golden Knights | ESPN+, SN-PIT, SCRIPPS | L 0-4 |
| Sun, Mar 9 | @ | Minnesota Wild | TNT, truTV, MAX, SN-PIT | W 3-1 |
| Tue, Mar 11 | vs | Vegas Golden Knights | ESPN+, SN-PIT, SCRIPPS | W 3-2 (OT) |
| Thu, Mar 13 | vs |   St. Louis Blues | ESPN+, SN-PIT, FDSNMW | W 5-3 |
| Sat, Mar 15 | vs | New Jersey Devils | ESPN+, ABC | W 7-3 |
| Tue, Mar 18 | vs | New York Islanders | ESPN+, SN-PIT, MSGSN | L 2-4 |
| Fri, Mar 21 | vs | Columbus Blue Jackets | NHLN, SN-PIT, FDSNOH | W 6-3 |
| Sun, Mar 23 | @ | Florida Panthers | ESPN+, SN-PIT, SCRIPPS | OTL 3-4 (SO) |
| Tue, Mar 25 | @ | Tampa Bay Lightning | ESPN+, SN-PIT, FDSNSUN | L 1-6 |
| Thu, Mar 27 | @ | Buffalo Sabres | ESPN+, SN-PIT, MSG-B | L 3-7 |
| Sun, Mar 30 | vs | Ottawa Senators | ESPN+, SN-PIT | W 1-0 (OT) |
| Thu, Apr 3 | @ | St. Louis Blues | ESPN+, SN-PIT, FDSNMW | OTL 4-5 (OT) |
| Sat, Apr 5 | @ | Dallas Stars | ESPN+, ABC | W 5-3 |
| Sun, Apr 6 | @ |   Chicago Blackhawks | ESPN+, SN-PIT, CHSN | L 1-3 |
| Tue, Apr 8 | vs | Chicago Blackhawks | ESPN+, SN-PIT+, WCIU | W 5-0 |
| Fri, Apr 11 | @ | New Jersey Devils | NHLN, SN-PIT, MSGSN | W 4-2 |
| Sun, Apr 13 | vs | Boston Bruins | TNT, truTV, MAX, SN-PIT+ | L 1-4 |
| Thu, Apr 17 | vs | Washington Capitals | ESPN | W 5-2 |
