| Tue, Oct 7 | vs |   Pittsburgh Penguins | ESPN | L 0-3 |
| Thu, Oct 9 | @ |   Buffalo Sabres | ESPN+, MSG, MSG-B | W 4-0 |
| Sat, Oct 11 | @ | Pittsburgh Penguins | ESPN+, MSG, SN-PIT | W 6-1 |
| Sun, Oct 12 | vs |   Washington Capitals | NHLN, MSG, MNMT | L 0-1 |
| Tue, Oct 14 | vs |   Edmonton Oilers | ESPN+, MSG | L 0-2 |
| Thu, Oct 16 | @ |   Toronto Maple Leafs | ESPN+, MSG | OTL 1-2 (OT) |
| Sat, Oct 18 | @ |   Montreal Canadiens | ESPN+, MSG | W 4-3 |
| Mon, Oct 20 | vs |   Minnesota Wild | NHLN, MSG, FDSNNO, FDSNWI | L 1-3 |
| Thu, Oct 23 | vs |   San Jose Sharks | ESPN+, MSG, NBCSCA | OTL 5-6 (OT) |
| Sun, Oct 26 | @ |   Calgary Flames | ESPN+, MSGSN | L 1-5 |
| Tue, Oct 28 | @ |   Vancouver Canucks | ESPN+, MSG | W 2-0 |
| Thu, Oct 30 | @ | Edmonton Oilers | ESPN+, MSG | W 4-3 (OT) |
| Sat, Nov 1 | @ |   Seattle Kraken | ESPN+, MSG, KHN/Prime, KONG | W 3-2 (OT) |
| Tue, Nov 4 | vs |   Carolina Hurricanes | HBO MAX, TNT, truTV, MSG | L 0-3 |
| Fri, Nov 7 | @ |   Detroit Red Wings | NHLN, MSG, FDSNDETX | W 4-1 |
| Sat, Nov 8 | vs |   New York Islanders | ESPN+, MSG, MSGSN | L 0-5 |
| Mon, Nov 10 | vs |   Nashville Predators | ESPN+, MSG, FDSNSO | W 6-3 |
| Wed, Nov 12 | @ |   Tampa Bay Lightning | HBO MAX, TNT | W 7-3 |
| Sat, Nov 15 | @ |   Columbus Blue Jackets | ESPN+, MSG, FDSNOH | W 2-1 (SO) |
| Sun, Nov 16 | vs | Detroit Red Wings | NHLN, MSG, FDSNDET | L 1-2 |
| Tue, Nov 18 | @ |   Vegas Golden Knights | ESPN+, MSG, SCRIPPS | L 2-3 |
| Thu, Nov 20 | @ |   Colorado Avalanche | ESPN+, MSG, KUSA, ALT, KTVD | L 3-6 |
| Sat, Nov 22 | @ |   Utah Mammoth | ESPN+, MSG, Utah16 | L 2-3 |
| Mon, Nov 24 | vs |   St. Louis Blues | NHLN, MSG 2, FDSNMW | W 3-2 |
| Wed, Nov 26 | @ | Carolina Hurricanes | ESPN+, MSG 2, FDSNSO | W 4-2 |
| Fri, Nov 28 | @ |   Boston Bruins | HBO MAX, TNT | W 6-2 |
| Sat, Nov 29 | vs | Tampa Bay Lightning | NHLN, MSG, The Spot | L 1-4 |
| Tue, Dec 2 | vs |   Dallas Stars | ESPN+, Victory+, MSG 2 | W 3-2 (OT) |
| Thu, Dec 4 | @ |   Ottawa Senators | ESPN+, MSG | W 4-2 |
| Sat, Dec 6 | vs | Colorado Avalanche | ESPN+, MSG, ALT | OTL 2-3 (OT) |
| Sun, Dec 7 | vs | Vegas Golden Knights | NHLN, MSG, SCRIPPS | OTL 2-3 (OT) |
| Wed, Dec 10 | @ |   Chicago Blackhawks | HBO MAX, TNT, truTV | L 0-3 |
| Sat, Dec 13 | vs | Montreal Canadiens | ESPN+, MSG | W 5-4 (OT) |
| Mon, Dec 15 | vs |   Anaheim Ducks | ESPN+, Victory+, MSG, KCOP-13 | L 1-4 |
| Tue, Dec 16 | vs | Vancouver Canucks | ESPN+, MSG | L 0-3 |
| Thu, Dec 18 | @ | St. Louis Blues | ESPN+, MSGSN, FDSNMW | W 2-1 (OT) |
| Sat, Dec 20 | vs |   Philadelphia Flyers | ESPN+, MSG, NBCSP | W 5-4 (SO) |
| Sun, Dec 21 | @ | Nashville Predators | ESPN+, MSG 2, FDSNSO | L 1-2 |
| Tue, Dec 23 | @ | Washington Capitals | ESPN+, MSG 2, MNMT2 | W 7-3 |
| Sat, Dec 27 | @ | New York Islanders | ESPN+, MSG 2, MSGSN | L 0-2 |
| Mon, Dec 29 | @ | Carolina Hurricanes | ESPN+, MSGSN, FDSNSO | OTL 2-3 (OT) |
| Wed, Dec 31 | @ | Washington Capitals | ESPN+, MSG, MNMT | L 3-6 |
| Fri, Jan 2 | @ |   Florida Panthers | HBO MAX, TNT, truTV | W 5-1 |
| Mon, Jan 5 | vs | Utah Mammoth | ESPN+, MSG, Utah16 | OTL 2-3 (OT) |
| Thu, Jan 8 | vs | Buffalo Sabres | ESPN+, MSG, MSG-B | L 2-5 |
| Sat, Jan 10 | @ | Boston Bruins | ABC | L 2-10 |
| Mon, Jan 12 | vs | Seattle Kraken | NHLN, MSG, KHN/Prime, KONG | L 2-4 |
| Wed, Jan 14 | vs | Ottawa Senators | ESPN+, MSG | L 4-8 |
| Sat, Jan 17 | @ | Philadelphia Flyers | ESPN+, MSG, NBCSP | W 6-3 |
| Mon, Jan 19 | @ | Anaheim Ducks | ESPN+, Victory+, MSG, KCOP-13 | L 3-5 |
| Tue, Jan 20 | @ |   Los Angeles Kings | ESPN+, MSG, FDSNW | L 3-4 |
| Fri, Jan 23 | @ | San Jose Sharks | ESPN+, MSG, NBCSCA | L 1-3 |
| Mon, Jan 26 | vs | Boston Bruins | NHLN, MSG, NESN | W 4-3 (OT) |
| Wed, Jan 28 | @ | New York Islanders | ESPN+, MSG 2, MSGSN | L 2-5 |
| Thu, Jan 29 | vs | New York Islanders | ESPN+, MSG, MSGSN2 | L 1-2 |
| Sat, Jan 31 | @ | Pittsburgh Penguins | ABC | L 5-6 |
| Thu, Feb 5 | vs | Carolina Hurricanes | ESPN+, MSG, FDSNSO | L 0-2 |
| Thu, Feb 26 | vs | Philadelphia Flyers | ESPN | OTL 2-3 (OT) |
| Sat, Feb 28 | vs | Pittsburgh Penguins | ABC | W 3-2 (SO) |
| Mon, Mar 2 | vs | Columbus Blue Jackets | NHLN, MSG, FDSNOH | OTL 4-5 (OT) |
| Thu, Mar 5 | vs | Toronto Maple Leafs | ESPN+, MSG | W 6-2 |
| Sat, Mar 7 | @ |   New Jersey Devils | ABC | L 3-6 |
| Mon, Mar 9 | @ | Philadelphia Flyers | ESPN+, MSGSN, NBCSP+ | W 6-2 |
| Tue, Mar 10 | vs | Calgary Flames | ESPN+, MSG | W 4-0 |
| Thu, Mar 12 | @ |   Winnipeg Jets | ESPN+, MSG | W 6-3 |
| Sat, Mar 14 | @ | Minnesota Wild | ESPN+, MSG, FDSNNO, FDSNWIX | W 4-2 |
| Mon, Mar 16 | vs | Los Angeles Kings | ESPN+, MSG, FDSNW | L 1-4 |
| Wed, Mar 18 | vs | New Jersey Devils | HBO MAX, TNT | L 3-6 |
| Thu, Mar 19 | @ | Columbus Blue Jackets | ESPN+, MSG, FDSNOH | L 3-6 |
| Sun, Mar 22 | vs | Winnipeg Jets | ESPN+, MSG | OTL 2-3 (SO) |
| Mon, Mar 23 | vs | Ottawa Senators | NHLN, MSG | L 1-2 |
| Wed, Mar 25 | @ | Toronto Maple Leafs | ESPN+, MSG | L 3-4 |
| Fri, Mar 27 | vs | Chicago Blackhawks | ESPN+, MSG, CHSN | W 6-1 |
| Sun, Mar 29 | vs | Florida Panthers | NHLN, MSG, SCRIPPS | W 3-1 |
| Tue, Mar 31 | vs | New Jersey Devils | ESPN+, MSG 2, MSGSN | W 4-1 |
| Thu, Apr 2 | vs | Montreal Canadiens | ESPN+, MSG | L 2-3 |
| Sat, Apr 4 | vs | Detroit Red Wings | ABC | W 4-1 |
| Sun, Apr 5 | vs | Washington Capitals | ESPN | W 8-1 |
| Wed, Apr 8 | vs | Buffalo Sabres | HBO MAX, TNT, truTV, MSG | L 3-5 |
| Sat, Apr 11 | @ | Dallas Stars | ESPN+, Victory+, MSG | L 0-2 |
| Mon, Apr 13 | @ | Florida Panthers | ESPN+, MSG, SCRIPPS | L 2-3 |
| Wed, Apr 15 | @ | Tampa Bay Lightning | ESPN+, MSG, The Spot | W 4-2 |
