| Wed, Oct 8 | @ |   Washington Capitals | HBO MAX, TNT | W 3-1 |
| Thu, Oct 9 | vs |   Chicago Blackhawks | ESPN+, NESN, CHSN | W 4-3 (OT) |
| Sat, Oct 11 | vs |   Buffalo Sabres | ESPN+, NESN, MSG-B | W 3-1 |
| Mon, Oct 13 | vs |   Tampa Bay Lightning | NHLN, NESN, The Spot | L 3-4 |
| Thu, Oct 16 | @ |   Vegas Golden Knights | ESPN+, NESN, SCRIPPS | L 5-6 |
| Sat, Oct 18 | @ |   Colorado Avalanche | ESPN+, NESN, ALT, KTVD | L 1-4 |
| Sun, Oct 19 | @ |   Utah Mammoth | NHLN, NESN, Utah16 | L 2-3 |
| Tue, Oct 21 | vs |   Florida Panthers | ESPN | L 3-4 |
| Thu, Oct 23 | vs |   Anaheim Ducks | ESPN+, Victory+, NESN, KCOP-13 | L 5-7 |
| Sat, Oct 25 | vs | Colorado Avalanche | NHLN, NESN, ALT | W 3-2 |
| Mon, Oct 27 | @ |   Ottawa Senators | ESPN+, NESN | L 2-7 |
| Tue, Oct 28 | vs |   New York Islanders | ESPN+, NESN, MSGSN | W 5-2 |
| Thu, Oct 30 | vs | Buffalo Sabres | ESPN+, NESN, MSG-B | W 4-3 (OT) |
| Sat, Nov 1 | vs |   Carolina Hurricanes | ESPN+, NESN, FDSNSO | W 2-1 |
| Tue, Nov 4 | @ | New York Islanders | ESPN+, NESN, MSGSN | W 4-3 (SO) |
| Thu, Nov 6 | vs | Ottawa Senators | ESPN+, NESN | W 3-2 (OT) |
| Sat, Nov 8 | @ |   Toronto Maple Leafs | ESPN+, NESN | W 5-3 |
| Tue, Nov 11 | vs | Toronto Maple Leafs | HBO MAX, TNT, truTV | W 5-3 |
| Thu, Nov 13 | @ | Ottawa Senators | ESPN+, NESN | L 3-5 |
| Sat, Nov 15 | @ |   Montreal Canadiens | NHLN, NESN | W 3-2 |
| Mon, Nov 17 | vs | Carolina Hurricanes | ESPN+, NESN, FDSNSO | L 1-3 |
| Wed, Nov 19 | @ | Anaheim Ducks | ESPN+, Victory+, NESN | L 3-4 |
| Fri, Nov 21 | @ |   Los Angeles Kings | ESPN+, NESN, FDSNW | W 2-1 (OT) |
| Sun, Nov 23 | @ |   San Jose Sharks | ESPN+, NESN, NBCSCA | L 1-3 |
| Wed, Nov 26 | @ | New York Islanders | ESPN+, NESN, MSGSN | W 3-1 |
| Fri, Nov 28 | vs |   New York Rangers | HBO MAX, TNT | L 2-6 |
| Sat, Nov 29 | vs |   Detroit Red Wings | ESPN+, NESN, FDSNDET | W 3-2 (SO) |
| Tue, Dec 2 | @ | Detroit Red Wings | ESPN+, NESN, FDSNDET | L 4-5 |
| Thu, Dec 4 | vs |   St. Louis Blues | ESPN+, NESN, FDSNMW | W 5-2 |
| Sat, Dec 6 | vs |   New Jersey Devils | ESPN+, NESN, MSG | W 4-1 |
| Tue, Dec 9 | @ | St. Louis Blues | ESPN+, NESN, FDSNMW | W 5-2 |
| Thu, Dec 11 | @ |   Winnipeg Jets | ESPN+, NESN | W 6-3 |
| Sun, Dec 14 | @ |   Minnesota Wild | ESPN+, NESN, FDSNNO, FDSNWI | L 2-6 |
| Tue, Dec 16 | vs | Utah Mammoth | ESPN+, NESN, Utah16 | W 4-1 |
| Thu, Dec 18 | vs |   Edmonton Oilers | ESPN+, NESN | L 1-3 |
| Sat, Dec 20 | vs |   Vancouver Canucks | NHLN, NESN | OTL 4-5 (SO) |
| Sun, Dec 21 | vs | Ottawa Senators | ESPN+, NESN | L 2-6 |
| Tue, Dec 23 | vs | Montreal Canadiens | ESPN+, NESN | L 2-6 |
| Sat, Dec 27 | @ | Buffalo Sabres | ESPN+, NESN, MSG-B | L 1-4 |
| Mon, Dec 29 | @ |   Calgary Flames | ESPN+, NESN | OTL 1-2 (OT) |
| Wed, Dec 31 | @ | Edmonton Oilers | ESPN+, NESN | W 6-2 |
| Sat, Jan 3 | @ | Vancouver Canucks | ESPN+, NESN | W 3-2 (OT) |
| Tue, Jan 6 | @ |   Seattle Kraken | ESPN+, NESN, KHN/Prime, KONG | L 4-7 |
| Thu, Jan 8 | vs | Calgary Flames | ESPN+, NESN | W 4-1 |
| Sat, Jan 10 | vs | New York Rangers | ABC | W 10-2 |
| Sun, Jan 11 | vs |   Pittsburgh Penguins | ESPN+, NESN, SN-PIT | W 1-0 |
| Tue, Jan 13 | vs | Detroit Red Wings | HBO MAX, TNT, NESN | W 3-0 |
| Thu, Jan 15 | vs | Seattle Kraken | ESPN+, NESN, KHN/Prime, KING 5, KONG | W 4-2 |
| Sat, Jan 17 | @ | Chicago Blackhawks | ESPN+, NESN, CHSN | W 5-2 |
| Tue, Jan 20 | @ |   Dallas Stars | HBO MAX, TNT, NESN | L 2-6 |
| Thu, Jan 22 | vs | Vegas Golden Knights | ESPN+, NESN, SCRIPPS | W 4-3 |
| Sat, Jan 24 | vs | Montreal Canadiens | NHLN, NESN | W 4-3 |
| Mon, Jan 26 | @ | New York Rangers | NHLN, NESN, MSG | OTL 3-4 (OT) |
| Tue, Jan 27 | vs |   Nashville Predators | ESPN+, NESN, FDSNSO | W 3-2 (OT) |
| Thu, Jan 29 | vs |   Philadelphia Flyers | ESPN+, NESN, NBCSP+ | W 6-3 |
| Sun, Feb 1 | @ | Tampa Bay Lightning | ESPN | OTL 5-6 (SO) |
| Wed, Feb 4 | @ | Florida Panthers | HBO MAX, TNT | OTL 4-5 (SO) |
| Thu, Feb 26 | vs |   Columbus Blue Jackets | ESPN+, NESN, FDSNOH | W 4-2 |
| Sat, Feb 28 | @ | Philadelphia Flyers | ABC | L 1-3 |
| Tue, Mar 3 | vs | Pittsburgh Penguins | ESPN+, NESN, SN-PIT | W 2-1 |
| Thu, Mar 5 | @ | Nashville Predators | ESPN+, NESN, FDSNSO | L 3-6 |
| Sat, Mar 7 | vs | Washington Capitals | ABC | W 3-1 |
| Sun, Mar 8 | @ | Pittsburgh Penguins | HBO MAX, TNT, truTV | OTL 4-5 (OT) |
| Tue, Mar 10 | vs | Los Angeles Kings | ESPN+, NESN, FDSNW | W 2-1 (OT) |
| Thu, Mar 12 | vs | San Jose Sharks | ESPN+, NESN, NBCSCA | L 2-4 |
| Sat, Mar 14 | @ | Washington Capitals | ABC | W 3-2 (SO) |
| Mon, Mar 16 | @ | New Jersey Devils | ESPN | OTL 3-4 (OT) |
| Tue, Mar 17 | @ | Montreal Canadiens | ESPN+, NESN | OTL 2-3 (OT) |
| Thu, Mar 19 | vs | Winnipeg Jets | ESPN+, NESN | W 6-1 |
| Sat, Mar 21 | @ | Detroit Red Wings | ABC | W 4-2 |
| Tue, Mar 24 | vs | Toronto Maple Leafs | ESPN+, NESN | L 2-4 |
| Wed, Mar 25 | @ | Buffalo Sabres | HBO MAX, TNT, truTV, NESN | W 4-3 (OT) |
| Sat, Mar 28 | vs | Minnesota Wild | NHLN, NESN, FDSNNO, FDSNWIX | W 6-3 |
| Sun, Mar 29 | @ | Columbus Blue Jackets | ESPN+, NESN, FDSNOH | W 4-3 (SO) |
| Tue, Mar 31 | vs | Dallas Stars | ESPN+, Victory+, NESNplus, FOX4 | W 6-3 |
| Thu, Apr 2 | @ | Florida Panthers | ESPN+, NESN, SCRIPPS | L 1-2 |
| Sat, Apr 4 | @ | Tampa Bay Lightning | ESPN+, NESNplus, The Spot | L 1-3 |
| Sun, Apr 5 | @ | Philadelphia Flyers | HBO MAX, TNT, truTV, NBCSP | OTL 1-2 (OT) |
| Tue, Apr 7 | @ | Carolina Hurricanes | ESPN+, NESN, FDSNSO | OTL 5-6 (OT) |
| Sat, Apr 11 | vs | Tampa Bay Lightning | ABC | L 1-2 |
| Sun, Apr 12 | @ | Columbus Blue Jackets | NHLN, NESN, FDSNOH | W 3-2 |
| Tue, Apr 14 | vs | New Jersey Devils | ESPN+, NESN, MSG | W 4-0 |
| Sun, Apr 19 | @ | Buffalo Sabres | ESPN, NESN, MSG-B | L 3-4 |
| Tue, Apr 21 | @ | Buffalo Sabres | ESPN, NESN, MSG-B | W 4-2 |
| Thu, Apr 23 | vs | Buffalo Sabres | HBO MAX, TNT, truTV, NESN, MSG-B | L 1-3 |
| Sun, Apr 26 | vs | Buffalo Sabres | HBO MAX, TNT, truTV, NESN, MSG-B | L 1-6 |
| Tue, Apr 28 | @ | Buffalo Sabres | HBO MAX, TNT, truTV, NESN, MSG-B | W 2-1 (OT) |
| Fri, May 1 | vs | Buffalo Sabres | ESPN, NESN, MSG-B | L 1-4 |
